The aim of this study is to find the anxiolytic activity of Ricinus Communis for the glycoside compound Kaempferol-3-O-beta-D-xyloside with the 18kDa translocator protein by molecular docking. The docking study was done for Kaempferol-3-O-beta-D- Xyloside from Ricinus communis using the translocator protein (18kDa). The Translocator protein ligands are promising candidates for fast-acting Anxiolytic drugs. Ricinus communis have been widely used in the traditional medicine such as abdominal disorders, arthritis, backache, muscle aches, chronic headache, sleeplessness. Kaempferol-3-O-beta-D- Xyloside is found in the dried leaves of the Ricinus communis. Ricinus communis is classified as the most poisonous plant on earth of humans. Anxiolytic agents treat the symptoms of anxiety, fear, uneasiness,