Topical drug administration is a localised drug delivery strategy that can be used anywhere in the body via ophthalmic, rectal, vaginal, and cutaneous channels. The skin is one of the most easily accessible organs on the human body for topical administration and serves as the primary channel of the topical medication delivery system. Fungus causes a variety of skin illnesses. An antifungal drug is a fungicide that is used to treat mycoses such as athlete's foot, ringworm, and candidiasis. Antifungals function by leveraging differences between mammalian and fungal cells to eliminate the fungal organism without causing harm to the host. Antifungal medicines are used to treat fungal infections. However, it has a limited bioavailability (55%) due to its low water solubility and first pass impact. Also. Many medications rely on the stratum corneum, the skin's outer layer, as a skin penetration barrier. Several strategies have been developed to circumvent this barrier, including the use of vehicles and nanocarriers to increase medication penetration. Recently, several types of nanocarriers have been devised to improve the dermal and transdermal administration of drugs like 'invasome'. This study provides a concise summary of fungal infections, invasome as a novel drug delivery method, formulation & evaluation of invasome, and marketed invasome formulations for treatment of various diseases.