Objective: To critically evaluate the existing evidence with respect to the effect of vibrational devices on the rate of tooth movement during orthodontic treatment. Materials and methods: Unrestricted electronic search in PubMed/ MEDLINE, DOAJ, Cochrane Central as well as manual searches was conducted upto June 2020. Only randomized controlled trials (RCTs) were included. Study selection, data extraction, and bias assessment were done by two independent reviewers. The Cochrane risk-of-bias tool was used, and the quality of evidence was graded using the GRADE approach. A fixed-effects meta-analysis of continuous data, with its 95% confidence intervals (CIs), was used. Results: The initial electronic database search resulted in 3528 titles. 37 articles were cited as duplicates. After screening the abstracts, 326 relevant titles were selected by two independent reviewers and were excluded for not being related to the topic. Following examination and discussion by the reviewers 14 articles were selected for full text evaluation. Hand searching of the reference lists of the selected studies did not deliver additional papers. After pre-screening, application of the inclusion and exclusion criteria and handling of the PICO questions, nine studies remained (two studies with no post intervention data, four studies were inappropriate for outcome of interest and two studies did not have the measures of effect as per the protocol). Seven studies were finally included in the qualitative synthesis which used for data extraction and statistical analysis. Out of the seven, four studies were included in the quantitative synthesis. Results also showed a statistically non-significant difference regarding the effect of vibrational devices on rate of tooth movement when compared with non- vibratory stimulus and sham devices. Conclusion: There is weak evidence of the effect and use of vibrational devices in increasing the rate of tooth movement in orthodontic treatment. The meta-analysis aided us to conclude that there is no significant difference in the rate of tooth movement outcome after use of vibrational devices as compared to control group in patients undergoing orthodontic treatment.