Background: The inclusion of healthcare professionals, such as pharmacists, nurses, and labs, in patient care has received more attention recently since it has the potential to enhance the quality and effectiveness of healthcare. Nonetheless, it is important to conduct a thorough examination of the current research in order to ascertain the effects of integrated care models that include these professions. Aim: This study seeks to examine the effects of integrated care models that include pharmacists, nurses, and labs on the quality and efficiency of healthcare. More precisely, the evaluation aims to combine current research about patient outcomes, cost reductions, and healthcare use in these models. Furthermore, the study seeks to analyze the distinct responsibilities and contributions of pharmacists, nurses, and labs in the context of integrated care. Method: A methodical search technique was used to locate relevant studies in electronic databases, such as PubMed, MEDLINE, and Cochrane Library. The inclusion criteria were centered on studies that documented the effects of integrated care models, which included the involvement of pharmacists, nurses, and labs, on the quality and efficiency of healthcare. Both quantitative and qualitative research were taken into account for inclusion. The data was analyzed using thematic synthesis to find important themes and patterns pertaining to the influence and responsibilities of healthcare professionals in integrated care models. Results: The evaluation determined that healthcare quality and efficiency had been positively affected by integrated care models that include pharmacists, nurses, and labs. The implications include improved patient outcomes, such as increased compliance with medication and better management of diseases, together with cost savings achieved by reducing hospital admissions and healthcare consumption. The distinct functions of pharmacists, nurses, and laboratories in these models were determined, emphasizing their responsibilities in drug administration, patient education, and diagnostic services, respectively. The research further found elements that contribute to the success of integrated care models, such as interprofessional cooperation and patient-centered care. Conclusion: This review offers a thorough comprehension of the influence of integrated care models including pharmacists, nurses, and labs on the quality and efficiency of healthcare. The results enhance the existing body of literature on integrated care models and provide valuable insights for future study and practice in this field. The study further provides suggestions for future research, implementation tactics, and policy implications to optimize the efficacy of integrated care models across various healthcare settings.