In alloxan-induced diabetic rats, hepatoprotective and blood glucose levels were assessed following oral administration of an ethanol leaf extract of Eclipta alba and Ziziphus jujube. The data obtained after oral treatment with the extract and glibenclamide for 7 and 21 days showed a comparable hypoglycemic impact. After 21 days, the greatest reduction in blood glucose level (15.18-26.7%) was seen. When compared to diabetic controls, the animals treated with a combined dose of plant extracts showed the greatest increases in GSH and SOD levels and a reduction in MDA levels. Additional research can reveal the plant drug's mechanism of action with regard to its hepatoprotective and anti-diabetic effects.