In the food and herbal medicine sector, substances like turmeric (Curcuma longa), neem leaves (Azadirachta indica), and lemongrass (Cymbopogon citratus) are widely employed. Recent reports indicated that these plants contain some phytochemicals which are known to have antioxidant properties. However, the synergistic antioxidant effects of the combination of these medicinal plant extracts have not been reported to date. This study was conducted to investigate the antioxidant potentials of individual and combination of turmeric, neem leaves, and lemongrass extracts. Methodology: The 2, 2-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay was used to assess the antioxidant activity of all the fresh plant extracts. There were 16 formulation trials with different proportions of extracts selected randomly. Results: When samples viz. LG 50%, NE 50%, and CE 50% extracts antioxidant activity are compared, it was found that Neem leaf extract showed the highest antioxidant activity followed by lemongrass leaves and turmeric extracts and the % antioxidant were recorded as 76.61%, 66.72% and 62.04% respectively. When samples containing LG 100%, NE 100% and CE 100% are compared, the result showed that the radical scavenging activity of Neem leaf and lemon grass leaf extracts were higher i.e. 94.43% and 92.17% respectively whereas, Turmeric extract gave only 87.17% radical scavenging activity. When two or three plant combinations are compared with individual plant extracts, the results showed that the combination of different extracts has significant antioxidant activity, indicating the synergistic interaction of the combination of two and three plant extracts. During the study, it was observed that some combinations of plant extracts showed significant antioxidant activity and some combinations of extracts showed non-significant activity. Conclusion: In this research study most plant combinations showed synergistic interactions in the DPPH radical scavenging assay. We suggest using only combinations of synergistic plant extracts for antioxidant activity should be used, and plant extracts having antagonistic activity should be avoided.