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ISSN 2063-5346
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INVESTIGATION OF IN-VITRO AND IN-SILICO ANTI-DIABETIC POTENTIAL OF DIETHYL PHTHALATE AND NANO PARTICLES (SILVER AND GOLD) WITH DIETHYL PHTHALATE

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M. Shirley Navis, Dr. Ragel Mabel Saroja, Jameer Ahamed. S
» doi: 10.53555/ecb/2022.11.10.73

Abstract

Impaired insulin synthesis (inhibitory action) or the cells' inability to utilise insulin that has already been created are the two main causes of diabetes, a chronic condition of the metabolism of carbohydrates, lipids, and proteins. Undiagnosed diabetes affects a large portion of population. It is now essential to screen for diabetes and to streamline the diagnostic procedures. Compared to synthetic drugs, herbal remedies are regarded to be safer and have fewer adverse effects. Certain plant-derived bioactive components, which are composed of various chemical components, have shown characteristics that favor their use in the treatment of non-insulin-dependent diabetic mellitus (NIDDM). According to the investigation, the enzymes amylase and glucosidase, which are linked to diabetes, were inhibited more effectively by silver nanoparticles with diethyl phthalate in the test samples. Through molecular docking against the target enzymes DPP4 complexed with syn-7aa (4n8d), Human pancreatic alpha-amylase (1HNY), and Human lysosomal alpha-glucosidase, the molecular interaction was assessed

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