Background. The COVID-19 pandemic has shown how much coronavirus infection can be contagious. Even now, doctors are facing the consequences of this viral disease. A high lesion of the pulmonary system causes an increase in the proportion of consequences of respiratory disease. One of the difficult aspects in this direction is lung abscesses. Material. An analysis of different approaches in the treatment of lung abscesses of patients who have had COVID-19 was carried out. All patients, depending on the severity of the course of purulent lung disease and treatment methods, were divided into 3 groups. Results. The main positive therapeutic effect in the treatment of lung abscesses in patients with COVID-19 should be reduced to the effects of endothelialitis. For this, long-term intraarterial catheter therapy and local ultrasound cavitation of the lung destruction cavity were used. Significant positive results were obtained in all major groups where a differentiated treatment approach was used. Conclusion. The use of the therapeutic and diagnostic algorithm developed by us leads to an improvement in the clinical, radiological and ultrasound picture of the disease, allows us to reduce the duration of inpatient treatment by 7 days, as well as improve clinical outcomes, including, to increase the proportion of patients with complete recovery by 23% and reduce the frequency of the transition of an abscess to a chronic form by half.