Endocrine-disrupting chemical (EDC) bisphenol A (BPA), which is frequently used in a range of plastics made of polycarbonate as well as epoxy resins as (plastic bottles and the of food cans lining), was found in over ninety percent of urine samples from people. EDC exposure and type 1 diabetic mellitus (T1DM) have both increased globally. Animal studies have demonstrated that BPA can worsen T1DM, despite the fact that there are still questions about BPA's potential link to T1DM risk. To compare the effects of low and high doses of BPA on blood glucose levels and histological alterations in the pancreas of the tested rats to the control groups, thirty male and thirty female adult albino rats were subjected to 20 and 100 mg/kg of bisphenol A orally every day for six weeks. The findings revealed a dose-dependent significant rise in blood glucose levels in all tested groups of rats compared to the control group as well as numerous observed pathological alterations in the pancreas that were more pronounced in female than in male rats. Conclusion: The study found that BPA treatment at various doses can disrupt glucose hemostasis and lead to islet degeneration and pancreatic histological abnormalities, which can be used to explain why blood glucose levels are elevated.