The objective of this research is to explore various factors related to the work environment and job satisfaction of nurses at RSI Sultan Agung. The research questions focus on investigating how work stress affects job satisfaction, how job satisfaction impacts nurses' performance, how work stress directly influences nurses' performance, and how work stress indirectly affects performance through job satisfaction as a mediator. This is an explanatory research study that involves a sample of 158 nurses selected from the total employee population of 262. Data was collected using questionnaires and documentation and analyzed through path analysis. The findings reveal that the majority of nurses (41.77%) have performance levels falling into both categories. The most prevalent category of job stress experienced by the nurses was moderate stress (25.32%), while job satisfaction was classified as unfavorable (29.11%). The research concludes that job stress has a positive impact on job satisfaction and performance. Whereas, the study indicates that job satisfaction does not act as an intervening variable between work stress and performance.