Background: Evidence strongly suggests that periodontal diseases are related to certain systemic diseases. An interdisciplinary approach is required for the diagnosis and treatment planning of these complex medical and dental conditions. This co-ordination is essential to help in achieving the best treatment outcome with long-term systemic and oral benefits to the patient. Objective: To assess and compare the knowledge and awareness about the interlace between periodontal disease and systemic health among interns and post graduates in Krishna Institute of Medical Sciences (KIMS). Methodology: A specially designed prevalidated questionnaire was developed, consisting of 15 questions, and was distributed through the electronic method in the form of Google form among interns and post graduate students of KIMS, KVV. The obtained data was statistically analyzed using the chi-square test. Result: A total of 179 responses were recorded, including interns and post graduates. Overall good knowledge was observed. Variations in the responses were observed concerning the periodontal-systemic connection. Good awareness was found about oral hygiene, drug-induced gingival changes etc. The focus should be improving knowledge about invasive periodontal therapy, complications of diabetes as well the requirement of referral etc.