Mania and depression are characteristics of bipolar disorder, formerly known as manic depression. In children and teenagers, depression frequently becomes a long-term illness. Teenagers and people with a history of mania were frequently observed to have mixed mania, especially females. The DSM of Mental Disorders was also expected to apply to about half of the hypomanic and manicpatients.Mixed feature specifies in the 5 Editionwith a sizable female predominance. Methods:It is a cross-sectional study,with a sample size of 145 participants.The study participants areB. Pharm, Pharm. D 2nd and above and alsoM.pharm students.The study instrument used is a validated questionnaire, circulated to the participants. The questionnaire consists of 4 sections.Thedata is collected and analyzed.Results:In our study questionnaire was circulated among 145 participants from pharmacy students. The study result showed that pharmacy students have knowledge, attitude, and practice about depression and mania in bipolar disorder. Conclusion:Most of our study participants were aware of bipolar disorder, risk factors, causes and symptoms of bipolar disorder. Both Males and Females haveSatisfactory knowledge, Attitude, and practice. So, improve knowledge Attitude and Practice of the disease and help in the betterment of the society. Recommend the provision of schools and training programs in the area of mental health, to increase the number of mental health professionals. Furthermore, the creation of awareness education programs on mental illnesses.