Objective: Our study involved a comparison of the laparoscopic-vaginal approach and the traditional abdominal approach for the treatment of patients diagnosed with endometrial cancer regarding pathological, operative, postoperative and oncological outcomes. Methods: This study is an RCT, fifty-six candidates with endometrial cancer were recruited and allocated to two groups, twenty-three patients each, laparoscopic group and laparotomy group. In this study, patients diagnosed with stage I, II endometrial cancer were randomly assigned to either Total laparoscopic hysterectomy (TLH); the intervention arm or Total abdominal hysterectomy (TAH) the standard arm in a 1:1 ratio. The randomization was performed using sequential number generation