Essential oils are naturally occurring complex mixtures of volatile odor compounds synthesized as secondary metabolites by plants. They widely used as therapeutic agents owing to their pharmacological and psychological properties. Lemongrass (Cymbopogon citratus) is grown as an ornamental plant and is used as a culinary and medicinal herb, the essential oil extracted from its leaves is widely known. It is recognized for its antioxidant activity and effective scavenging mechanism for free radicals through its potent flavonoid and phenol components, besides, it is available in different countries and extensively used in medicine and industry. The purpose of this review article is to gather the information on Lemongrass regarding chemical composition and its extraction, and some potential health benefits and ameliorative effects on different toxic exposure., it is important to recommend using Lemongrass essential oil as food supplement to decrease the risk of diseases associated with daily toxic environmental exposure.