Background:Small incision lenticule extraction or SMILE is a novel form of „flapless‟ corneal refractive surgery that was adapted from refractive lenticule extraction (ReLEx), Aim:The aim of this study is to evaluate whether SMILE is non-inferior to LASIK in terms of refractive outcomes. Methods: this was a randomized clinical trial, had included 60 eyes of 31 patients in the study undergoing SMILE for correction of myopia between July 2016 and July 2019. They were divided into two groups: 30 eyes for continuous curvilinear lenticulerrhexis (CCL) technique (group A), and 30 eyes for traditional technique group (group B). Results: Mean BLM at 1 day postoperatively were 3.73 and 6.6 in groups A and B, respectively. Statistically significant difference was found between the two groups (P = 0.01). Mean BLM at 3 months postoperatively were 3.00 and 4.73 in groups A and B, respectively. No statistically significant difference was found between the two groups (P = 0.06). Conclusion:This novel trial will provide information on whether SMILE has comparable, if not superior, refractive outcomes compared to the established LASIK for myopia, thus providing evidence for translation into clinical practice.