Since the dawn of time, people have used plants for medicinal purposes. This knowledge has been central to developing many traditional medical practices, including the Indian system of medicine like Ayurveda, Siddha, Unani, Homeopathy, Naturopathy, and other medicine systems, including Tibetan, Chinese, and Native American medicine. According to the WHO, 80% of the global population uses herbal medicines for basic medical requirements. The usage of herbal products has risen due to increased perception, health consciousness, the belief that prevention is preferable to cure, and natural approaches to healthy living. The science of Rasayana in Ayurveda is concerned with enhancing overall health, energy, and vitality. Due to its energizing, reviving, and lactogenic characteristics, Leptadenia reticulata (Jivanti) stands out among the other plants used in Rasayana. This herb's medicinal potential is due to various bioactive components, including phytosterols, terpenoids, pregnane glycosides, fatty acids, phenolic acid, flavonoids, and other chemical components. Several conditions, including hematopoiesis, diabetes, emaciation, cough, dyspnea, fever, burning sensation, night blindness, and dysentery, are treated with L. reticulata. This plant is one of the key components included in many herbal preparations. The current study aims to gather the knowledge currently accessible on the pharmacological, phytochemistry, botanical, Ethnopharmacology, Toxicity study, marketed products, and patents of L. reticulata.