The scaffold benzimidazole plays an emerging role in the synthesis of significant biological active compounds. The term “Green Chemistry” is the advancement in the field of chemistry to synthesize compounds by adopting new eco-friendly strategies. By using gentler reagents and more environmentally friendly synthetic techniques, these green approaches reduce environmental contamination and the risk to human health. Further, these synthetic processes are included solvent-free reactions, uses of different catalysts, water as a solvent, ionic liquids, microwave-assisted synthesis, etc. In this review, we concentrate on the various catalysts used in the production of derivatives of 2-substituted benzimidazoles