CKD at all stages is accompanied with impaired lipid metabolism that not only favours the pathogenesis of atherovascular diseases but also facilitates the progression of the disease. As the renal function declines, oxLDL (oxidized LDL) and HDL impairment becomes more prominent and serves as important biomarkers for prediction of CVD risks in CKD. Therefore, this study was framed with an aim to evaluate lipid profile in the patients with CKD and compare that with the healthy control. Methods: This study included 60 healthy controls and 60 CKD patients. In both the groups, total cholesterol (TC), LDL, HDL, triglyceride (TG) and VLDL were estimated using standard kit based methods. Statistical analysis was done using student’s t test and ANOVA. Results: TC, LDL, TG and VLDL concentration increased significantly in the CKD patients compared to the control group. The level of HDL was low but the difference in mean value was insignificant. As the renal impairment progressed, the values of lipid parameters (TC, LDL, TG and VLDL) progressively increased while HDL decreased. Conclusion: Our study showed that the patients with CKD have atherogenic lipid profile that put them at an increased CVD risks. Hence, timely diagnosis by screening with lipid profile assessment along with therapeutic intervention and life style modification is suggested to prevent the associated long term cardiovascular complications.