The morbidity and mortality rates linked with healthcare-related infections in hospitals and other long-term care facilities are significant. Despite the fact that infection prevention and control (IPC) recommendations are clearly defined in the acute care context, there is a lack of information about the usefulness of these guidelines in long-term care facilities (LTCF). As a result, we conducted a literature review to investigate the risk of getting healthcare-associated infections in long-term care settings and the techniques that might be used to avoid these infections. Therefore, the most fundamental and essential IPC measures from the acute care setting, such as standard hygiene measures with hand hygiene and personal protective equipment when it is required, along with a good education for healthcare workers and a surveillance system that is operational, could be the cornerstones of a successful IPC program in long-term care.