The sellar and suprasellar region is an anatomically complex area where a spectrum of the possible pathologies is extremely wide, and includes both neoplastic and non-neoplastic masses. The lesions arising not from the pituitary gland itself, but also from vestigial embryological residues or surrounding tissues, that may require different therapeutic approaches. This article reviews the anatomy, embryology, and pathologic processes that occur in this region as well as the MRI imaging findings for these lesions.