Background: This study was conducted to address the Management of Endo-Perio lesions. Material and methods: In this study, 100 individuals with periodontitis were enrolled who had been identified with grade 2-3 endo-periodontal lesions on their teeth. According to the clinical symptoms and characteristics of the affected teeth following nonsurgical treatment for both the endodontic and periodontal components, they were separated into high and low responder groups. Before and after therapy, clinical parameters and symptoms were examined, and using univariate analysis, gender, age, smoking, and all clinical parameters were compared between high and low responder groups. To assess the independent impact on the prognosis of endo-periodontal lesions, logistic regression was used.