Oral cancers are common disease which disfigures tissues and require resection of maxilla, mandible floor of the mouth, and tongue. Resection of tissues without reconstruction causes mandibular deviation towards the resected side which depends on amount soft and hard tissue resected, surgical site closure, loss of proprioceptive sense of occlusion and timing of prosthodontic therapy. Rehabilitation of such patients (with non-reconstructed defects) starts with physical therapy and prosthodontic therapy to reduce deviation and scar contraction. This case report explains the fabrication of fixed mandibular guide flange prosthesis. The guide flange corrects the mandibular deviation and assist patient to close in maximum intercuspal position.