AIM To assess plasma concentrations of transdermal diclofenac patch (Nupatch) with the aid of Dimethyl Sulfoxide (DMSO) as a chemical skin permeation enhancer in post-operative pain management. OBJECTIVES:  To assess the pain levels using Visual analog scale  To assess plasma levels of diclofenac diethylamineby means of UV-spectrophotometry RESULTS: The Visual analog scores and the plasma diclofenac concentrations show that the patients from the study group demonstrated increased amounts of plasma dimethyl sulfoxide was used an adjuvant to increase the absorption from the Diclofenac diethylamine 200mg Transdermal patch ( Nupatch ) shown to have better pain scores and high plasma CONCLUSION: Chemical permeation enhancer (Dimethyl sulfoxide) as an adjuvant, one of the modalities available. UV spectroscopy studies revealed increased plasma concentrations of drugs (NSAIDSDICLOFENAC DIETHYLAMINE) for longer duration which facilitate better management of pain helping the patient recover when compared to patients either on transdermal patches alone, oral or I.V drug administration.