Coronavirus disease 2019 (COVID-19) is an infectious virus caused by the virus coronavirus 2 resulting in severe acute respiratory syndrome (SARS-CoV-2), which has had a terrible impact on the world, affecting nearly six million individuals. During the COVID-19 pandemic, a link has been observed between COVID-19 infection and acute cardiac injury, which may be related to abnormal levels of inflammation coagulation biomarkers such as troponin, C-reactive protein (CRP), and D-dimer in serum. However, there is currently no agreement on the incidence of cardiac injury, its prognosis, or its possible causes. Therefore, this article presents a detailed analysis and review of the incidence, comorbidities, outcomes, and potential mechanisms of acute cardiac injury in COVID-19 patients. Aims and objectives: We aimed to detect the rise of various parameters in covid 19 effected patients Material and methods: This was a cross-sectional, observational study conducted between 12/11/2020 and to may 2021 in covid-19 positive patients and controls. Participants were either gender and age ≥18; Ability to read, understand text and communicate language; and consent to personal data processing. Lack of access of internet. Inability of complete an online survey. Incomplete data in any section of the questionnaire. A total number of RT-PCR-confirmed COVID-19 patients were ordered for a panel of biochemistry tests such as RBS, Urea, Creatinine, T.bil, D.bil, Liver enzymes, Albumin, total protein, Ferritin, D-dimer, Troponin-I, CBP. A total of 190 COVID-19 patients were included in the study. SARS-CoV-2 infection was confirmed by the RT-PCR assay conducted in accordance with the standard protocol. Results: COVID-19 patients divide into mild, moderate, and severe. These include shortness of breath, chest pain, tachycardia, and hematological parameters such as WBC and platelet, neutrophil, and lymphocyte and coagulation markers such as D-dimer and troponin-I and liver enzyme abnormalities described to be associated with COVID-19 patients. This study has conducted at a tertiary care hospital with a total number of patients was 132 and 132 controls. All these markers are slightly elevated in patients with COVID-19. Determination of coagulation factors such as D-dimer in hospitalized covid-19 patients evidenced a consistent association during the patient’s hospital stay. Conclusion: Biomarkers will play a crucial role in early suspicion, diagnosis, monitoring, and recognition of complications, management and disposition of patients. Each of these components in turn can have crucial implications on the healthcare system and the administrative machinery, directly impacting patient care.