Microorganisms frequently live in biofilms in both natural and artificial environments. The mechanisms through which biofilm-dwelling cells exhibit better tolerance to antimicrobial drugs than free-living cells have been extensively investigated utilising single-strain axenic models. Interspecies interactions, yet, may significantly affect how the community reacts to such harmful exposure, according to mounting scientific data. We offer an overview of the research on multispecies biofilm resistance to disinfectants in this study, paying particular attention to how local surface flora protects pathogenic species against disinfection procedures. Interspecies signalling, dispute among biocides molecules and public goods in the matrix, or the physiology and genetic plasticity related with a structural spatial arrangement are some of the mechanisms involved in this protection.