Background:This globe is now seeing a pandemic epidemic of 'COVID-19′ produced by an RNA virus 'SARS-CoV-2'. Millions have died as a result of the sickness, and the number is growing by the day. The viral genome infects the human host via contact with the spike protein (S) and host GRP78, TMPRSS22. Most of the recently introduced vaccines across geographies, commonly target S. A recent increase in single/multiple mutations in the S region is cause for worry since it may evade vaccineinduced immunity. So far, the repurposed medicine therapy regimen has not proven very successful