Momordica charantia (karela) is a medicinal plant that has been traditionally used for its various health benefits. In recent years, numerous research studies have investigated the potential therapeutic properties of karela, including its antioxidant, immune-boosting, weight loss, and diabetes management properties. This literature review summarizes the findings of recent studies (2019-2022) on the medicinal uses of karela. The results of these studies suggest that karela has significant potential as a natural remedy for various health conditions, including digestive disorders, skin disorders, respiratory disorders, and diabetes. The antioxidant and immune-boosting properties of karela may also help prevent chronic diseases such as cancer and cardiovascular disease. Further research is needed to fully understand the mechanisms of action of karela and its bioactive compounds.