The objectives of this research article are 1) To study the circumstances and challenges faced by meditation practitioners, 2) To study the relationship between mental health and mindfulness-based practice, and 3) To provide recommendations for a mindfulness-based program to enhance mental health in meditation practitioners. The article is the qualitative research, used a qualitative research approach, and with in-depth interviews conducted among 10 key informants who are experienced meditation practitioners with over 5 years of practice. The research results show that 1) meditation practitioners experience various problems such as stress, being in the thinking loop, loss of temper, seeking acceptance, worry over uncontrollable external factors, inability to control their words, gaining weights, stress, anger, nervousness, and depression. 2) The cultivation of the four foundations of mindfulness can lead to significant improvements in mental health. 3) The key informants are found to develop their mental health through daily practice and participation in a one-day mindfulness-based program. Mindfulness-based activities include mindful sitting, walking, bowing, sleeping, speaking, listening, and eating