Merkel cell carcinoma is a very rare disease and a highly aggressive primary cutaneous neuroendocrine carcinoma primarily affecting elderly and immunosuppressed individuals. MCCs are positive for epithelial and neuroendocrine markers, but are negative for lymphoid and melanoma markers. Tumor genesis is still unclear, but recent works have suggested that epidermal stem cells and/or dermal neuroendocrine stem cells might be the MCC source. Authors present a series of 6 cases diagnosed in our laboratory with Merkel Cell Carcinoma. One is located in ala nasi dexter, one in region genu sinister, and 4 sites of metastatic lymph nodes. The distribution according to gender is 2 male and 4 female. The age is from 55 years old to 74 years old. A correct differential diagnosis between other similar pathologies is important to proceed with a multidisciplinary approach and treatment.