To create once-daily composition, the floating microspheres were used to provide extended and uniform release in the stomach. Short processing times, little exposure of materials to high temperatures, and high encapsulation effectiveness are main benefits of this technique. The manufacture of metformin hydrochloride floating microspheres, assessment of the in vitro release from the Floating Drug Delivery System, and adjustment of the floatation and drug release pattern to meet the desired release profile were all examined in the current work. Using the Eudragit RS100 controlling polymer and 250 mg of metformin hydrochloride per batch, floating microspheres were created