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ISSN 2063-5346
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BIOCHEMISTRY OF FASTING – A REVIEW ON METABOLIC SWITCH AND AUTOPHAGY.
Volume - 13 | Issue-1
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ONE-POT ENVIRONMENT FRIENDLY SYNTHESIS OF IMINE DERIVATIVE OF FURFURAL AND ASSESSMENT OF ITS ANTIOXIDANT AND ANTIBACTERIAL POTENTIAL
Volume - 13 | Issue-1
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MODELING AND ANALYSIS OF MEDIA INFLUENCE OF INFORMATION DIFFUSION ON THE SPREAD OF CORONA VIRUS PANDEMIC DISEASE (COVID-19)
Volume - 13 | Issue-1
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INCIDENCE OF HISTOPATHOLOGICAL FINDINGS IN APPENDECTOMY SPECIMENS IN A TERTIARY CARE HOSPITAL IN TWO-YEAR TIME
Volume - 13 | Issue-1
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SEVERITY OF URINARY TRACT INFECTION SYMPTOMS AND THE ANTIBIOTIC RESISTANCE IN A TERTIARY CARE CENTRE IN PAKISTAN
Volume - 13 | Issue-1
METHOD DEVELOPMENT AND QUANTITATIVE ESTIMATION OF ACAMPROSATE CALCIUM USING RP-HPLC
Main Article Content
Abstract
Objective: To develop and validate economic, user friendly, precise, specific and accurate RP-HPLC method for Acamprosate calcium. Methods: The RP-HPLC method uses Reverse phase C18 column (Comosil) (4.6 X 250mm, 5μm), a mobile phase of acetonitrile, (0.5%) at flow rate 0.7 ml/min, at 25oC ± 2oC and detection wavelength was set at 210 nm. Results: The developed method of RP-HPLC displayed linearity in the range of 2.9 to 22.6 part per million. The specificity obtained indicated non-interference from other impurities. The LOQ for acamprosate calcium obtained to be 39:1 and LOD for acamprosate calcium obtained to be 13:1.
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