This paper aimed to prepare and evaluate capsules containing novel microsponges loaded with Clotrimazole and Allicin to provide antifungal activity for vaginal candidiasis. Methods: Capsules are prepared by HPMC, which are incorporated with clotrimazole and allicin. Microsponges are prepared by Quasi emulsion technique using EC, PVA, and BCD for clotrimazole microsponges and Eudragit RS100, PVA for Allicin Microsponges. These microsponges are characterized by SEM, FTIR, DSC, and Particle size analysis and evaluated for drug loading capacity, percent yield, encapsulation efficiency, also in-vitro drug release studies. Result: FTIR & DSC studies show that no chemical interaction occurred between drug and polymer, and the batch shows good drug release and % yield Conclusion: The created microsponge formulation has the potential of a vaginal candidiasis treatment. The microsponges are a viable remedy substitute due to their better physicochemical characteristics, prolonged drug release, and sustained action. It is necessary to conduct additional clinical studies to confirm their safety and efficacy.