The present article is written intending to incorporate the information and compilation of advancement in the field of novel drug delivery systems (NDDS) with special emphasis on microsponges and nanoparticles in the delivery of drugs for the treatment of topical skin infections. Microsponges have several characteristics that make it a versatile drug delivery system. These are generally used for topical applications for the slow release of a drugs that can prevent excessive accumulation of ingredients at epidermis and dermis. Microsponges are too large to be adsorbed on the skin and prevent pathogens to enter the skin by entrapping in their structure. Nanoparticles (NPs) are the ultrafine particles with a size of less than 100 nm that offers a large surface area while applying on skin. NPs are now used in a wide variety of products and various technologies due to their uniformity and low toxicity. The development of NDDS of skin disorder drugs with special attention to microsponges followed by nanoparticles as an evolution to overcome the drawbacks of conventional delivery systems and enhancing the user acceptability.