The Sweet lime (Citrus limetta) is one of the world's most important commercial fruits. Several bioactive and volatile components can be found in sweet lime. The current work investigated a methanolic extract of Sweet lime peel retrieved using Microwave Assisted extraction (MAE) to assess bioactive components, different phytochemicals, and antioxidant activity, revealing that total phenolic content (TPC) is 16.66 mg GAE/g. Total flavonoid content (TFC) was found to be mg 9.59 QE/g, respectively, and in vitro free radical scavenging activity was found 77.62% The existence of 34 components was shown by GC-MS analysis, 12 of which were phytochemical components having antibacterial, antioxidant, and anticancer activity. The current results of this analysis demonstrate the existence of crucial phytocompounds in SLP and are useful for further in-depth research into generating functional foods from SLP to avoid a variety of ailments. The current research is targeted at identifying all-natural therapeutics for a broad range of illnesses and conditions.