The use of Schiff's bases in the creation of bioactive molecules is incredible. Many of these methods require a lot of energy and involve risky substances, solvents, and expensive work-ups. Large amounts of organic waste are produced by complicated processes and low yields. Researchers therefore concentrated on safe and environmentally friendly methods to construct heterocyclic analogues and medicinal compounds. To overcome the drawbacks associated with the conventional method for the synthesis of Schiff’s bases the new methodology uses microwave as an energy source for the organic synthesis. Microwave assisted method for preparation of the target organic moieties often facilitates higher product yields than any other approaches. The advantages of Microwave irradiation synthesis are solvent free or lower solvent conditions are a good method for reducing the pollution, lowering the cost, and increasing the product together with simplicity in processing and handling.