Inflammation is a complex physiological response that plays a pivotal role in various chronic diseases. Identifying natural compounds that can effectively modulate inflammatory pathways has become a promising approach in drug discovery. Stevioside, extracted from the Stevia rebaudiana plant, is known for its natural sweetness and has been extensively studied for its potential anti-inflammatory properties. In this study, we employed molecular docking analysis to investigate the potential of stevioside as a candidate with high binding affinity against key inflammatory targets, namely Interleukin-1β (IL-1β), Interleukin-6 (IL-6), leptin, and Tumor Necrosis Factor-α (TNF-α). Using computational tools and available crystal structures of the target proteins, we conducted molecular docking to predict the binding interactions between stevioside and the inflammatory targets