On the newly synthesized 16 piracetam butanamide derivatives (antiepileptic drugs), molecular docking investigations were done. The molecular docking of all the antiepileptic drugs was carried out using Pyrx software's Autodock Vina version 4.0. Gamma-aminobutyric acid aminotransferases (GABAAT) were used in molecular docking analyses to determine which piracetam butanamide derivatives (antiepileptic drugs) had the highest binding affinity, which was determined to be -3.7 kcal/mol. When enhancing the inhibitory actions of the piracetam butanamide derivatives against the GABAAT enzyme, which causes epilepsy, physicochemical characteristics must be taken into account