Hepatocellular carcinoma is sixth major widespread cancer and the third major reason of global death caused by different types of cancer. It is crucial cause for cancer deaths among almost 80% of total liver cancers. The miRNAs are non-coding endogenous, single-chain, small RNA of approx 20-24 nucleotides having role in post-transcriptional regulation of gene expressed in the organisms by influencing either stability or translational step of mRNAs. LHPP (Phospholysine Phosphohistidine Inorganic pyrophosphate Phosphatase) is a new class of inorganic pyrophosphatase, believed to be crucial for life and having role in the tumor suppression. Here in current research work a successful attempt has been made for the docking of ligand LHPP, an anti-cancerous protein with the earlier prepared molecular models of miRNAs such as miR-21, 155, 221 & miR-224.