This scoping review's goals were to thoroughly explore the existing understanding of the cellular and molecular mechanisms that underlie and regulate trauma, to explain the actual concept of TFO along with its background, etiology, signs, and symptoms, relation to periodontal elements, peri-implantitis, and cutting-edge diagnostic techniques, to identify knowledge gaps, and to provide the groundwork for more effective prevention and treatment. There are two schools of thought regarding the impact that trauma from occlusion has on the periodontium with respect to periodontal disease. One contemplates that occlusion-related stress plays a codestructive role in the development of periodontal disease. The other reasons it is not.