Endodontic procedures like root canal treatment, post and core, etc., makes the root of the tooth brittle. This leads to the generation of monoblock concept in endodontics, which is directly related to the endodontic rehabilitation of weakend tooth structure. Monoblock concept can be achieved by using single-cone obturation technique of prepared root canal along with sealer, providing adhesion between the sealer and the dentinal tubules and, between the sealer and the obturating cones. However, some researchers focused that creation of monoblock is challenging in complex anatomical structure of root canal like fins, isthmuses, etc. This article reviewed the concept of “monoblock” and its various application to different endodontic materials used in root canal space rehabilitation.