AIMS AND OBJECTIVE : To evaluate morbidity and mortality profile in children admitted to pediatric intensive care unit (PICU) and to assess the usefulness of PRISM III score in predicting mortality in PICU . MATERIALS AND METHODS: It is a cross sectional,hospital based prospective observational study done in department of pediatrics , PICU, MKCGMCH,Berhampur from october 2019 to september 2021 taking 105 cases. Information collected on study population during admission to PICU included patient details, provisional diagnosis, primary system involved, PRISM III scoring1(systolic BP, temp, heart rate, mental status, pupillary response, blood gas analysis ,glucose, potassium ,creatinine, hematological parameters) was done. Patient’s course of hospitalisation in PICU was monitored and requirement of ventilator and type (invasive/ non invasive), duration were recorded. Final outcome was whether shifted to general ward / discharged/ death/ LAMA/ referral to higher centre was recorded. Statistical analysis was done between PRISM III score value and outcome of patients and discriminative power of the score between survivor and death was analysed. RESULTS: Total 105 patients were analysed . most common age group was infancy and male to female ratio of 1.4:1. Most common indication for admission to PICU was respiratory diseases (n=38,36%)followed by neurological diseases(19,18%). Total death was (n= 27, 25%)among case studied.Among respiratory cases majority was pneumonia (n= 26, 68.4%). Total 63 cases (60%)