Drug delivery by fusing the medication to a carrier particle such as liposome, mucoadhesive microsphere, nanoparticle, etc. Drug delivery through mucoadhesive microsphere plays a major role in novel method of drug delivery. Due to their effective qualities like small size, sticking nature to the mucosal surface and release the medicine over an extended period of time, mucoadhesive microspheres improve drug absorption. Emulsion cross-linking, single emulsion, ionotropic gelation, phase inversion, spray drying, solvent removal, and hot melt techniques can all be used to generate these systems. These mucoadhesive devices can protect the drug both during transit to the delivery site and throughout absorption. This review provide an overview of the many mucoadhesive microsphere components that depend on various polymers, as well as their preparation, evaluation, advantages, disadvantages and drug delivery applications.