Objective: This case report aims at presenting extensive oral rehabilitation through multidisciplinary management of orofacial deformity due to cleft lip and palate in a young boy. Method: Growth modification was achieved through maxillary protraction using modified Tandem traction bow appliance. Simultaneous maxillary arch expansion was achieved through hyrax appliance to overcome the transverse discrepancy associated with retrusive maxilla. Orthodontic alignment of teeth was done using fixed orthodontic appliance. Secondary alveolar bone grafting was done using bone harvested from iliac crest to treat the palatal as well as unilateral alveolar cleft. This was followed by closure of oroantral fistula using a pedicle flap and aesthetic lip repair. Prosthetic replacement of missing anterior teeth was done. Findings: A 12-year-old boy presented with unilateral cleft palate sectioning the alveolar ridge between canine and central incisor on right side and extending up to posterior region of hard palate. A mid-palatine oronasal fistula was present associated with hypernasality of speech and nasal regurgitation. Extraoral examination of the patient revealed a concave profile, leptoprosopic facial type, and positive lip step. Intraoral examination of the patient revealed Angle class III subdivision malocclusion with anterior crossbite, reverse jet of -8mm, severely rotated maxillary central incisors, missing lateral incisors and crowding of lower anteriors. Novelty: Successful oral rehabilitation in patients with cleft lip and palate is extremely challenging and requires interdisciplinary team management. This patient had severe skeletal, dental and soft tissue deformities leading to compromised oral function and facial aesthetics affecting his physical and psychological wellbeing. Meticulous treatment planning with prompt initiation of growth modification combined with timely surgical interventions and orthodontic alignment of teeth lead to significant improvement in oral function and dentofacial esthetics in this patient