he COVID-19 coronavirus pandemic defines the current global health crisis and is humanity’s biggest challenge since World War Two. Remdesivir (GS-5734), chloroquine, hydroxychloroquine, and theaflavin are antiviral medications used to treat COVID-19, but they are ineffective for treating coronavirus patients who are hospitalized. By gathering information from the molecular graph, a topological index is a useful tool for predicting molecules’ various physical and chemical properties. Additionally, employed to research the biological effects of chemical compounds. The antiviral medications investigated in this paper, we have found their multiplicative degree-based topological indices, and the findings can be used to develop new or better COVID-19 treatment options. For further analysis of how the parameters in play affected our computed results, we also plotted them.