The indoor environment comprises air quality and working conditions. Indoor work environmental condition is significant as they affect the comfort, health, and performance of occupants. Industrial indoor environments differ from residential ones due to the adoption of manufacturing processes and the use of a variety of raw materials. Workplace environmental condition is assessed by evaluating various comfort and pollution parameters. This study was carried out in the textile dyeing and printing industry. In this study, fifteen parameters were considered to evaluate work environmental conditions in the industry. The stenter machine area and printing machine area were two locations selected based on the manufacturing process. Continuous monitoring had been carried out at the selected locations for 5 days in the winter, summer and monsoon seasons. Data on the selected parameters were recorded at minute intervals. Principal component analysis was performed to determine the parameters that significantly affect the indoor work environment. The results obtained show that the WBGT index at every place was higher than the prescribed norms. The average concentration of particulate matter, nitrogen dioxide and ozone was also observed higher. Principal component analysis at both locations indicated thermal comfort factors dominated the indoor work environment, followed by particulate matter, nitrogen dioxide, ozone, and a total volatile organic compound. The analysis revealed that water, high temperature, and chemicals were the major sources of indoor air pollution.