This review enhances recent advances in the field of nano-based platforms for antimicrobial photodynamic therapy (aPDT) targeting pathogenic oral biofilms. Background data: It is challenging to disinfect dental tissues in a clinically appropriate manner using aPDT alone. Limited penetration into both soft and hard oral tissues, photosensitizer diffusion, and the low light absorption coefficient have all been determined to be contributory factors. As a result, aPDT's efficacy in in vivo applications is diminished. Nanotechnology has been suggested to improve the penetration and delivery of photosensitizers to target bacteria and increase the bactericidal action in order to overcome constraints. Materials and methods: The current literature was screened for the various platforms composed of photosensitizers functionalized with nanoparticles and their enhanced performance against oral pathogenic biofilms Results: The evidence-based findings from the up-to-date literature were promising to control the onset and the progression of periodontal diseases. Conclusions: The promise of nano-based platforms to treat pathogenic oral biofilms, which are currently out of reach, has generated excitement. These nano-based platforms' novel modes of action, which enable us to get beyond the difficulties of intra-oral and hard-tissue disinfection, account for a large portion of their potential.