Alzheimer's disease (AD) is a neurobiological disorder that impairs motor and cognitive function. Currently available drugs like acetylcholinesterase inhibitors fail to prove their efficacy due to poor brain permeability, lower solubility, and slow bioavailability. Blood brain barrier and enzymatic degradation are major challenges for the treatment of AD. Herbal drugs and phytoconstituents have proven their efficacy in the treatment of this disease. Phytoconstituents also have poor availability across BBB as well as less systemic bioavailability which are major obstacles for their use but since this approach reduces systemic toxicity thus these medicines are more researched and promoted for treatment of neurological diseases like AD. Nanotechnology improves BBB permeability and bioavailability of drug. This technology can be used to improve bioavailability as well as BBB penetrability of phytoconstituents used for the treatment of AD. Nanocarriers have variable and interesting features that can be used with plant based medicines for the treatment of AD.This review summarizes the impact of nanotechnology on the development and improvement of efficacy of phytoconstituents for effective treatment of AD.