The Blood Brain Barrier (BBB) poses a significant obstacle to medication transport to the CNS because of the compressed endothelial interconnections of capillaries at its interface. Many delivery approaches have been tried in an effort to develop a brain-targeted delivery system with a desirable combination of properties, with BBB penetration being among the most crucial. Because of their diminutive size, NLCs may cross the BBB passively, releasing their contents gradually over time and protecting the encapsulated medication from breakdown while it travels to the targeted site. Furthermore, the Nano carrier’s surface can be functionalized to create a targeted delivery system. Drugs trapped in NLCs may be delivered in a variety of methods, including intranasally, intravenously, or orally, and the process is completely non-invasive. This review discusses the use of NLCs through different routes of administration for the treatment of neurological diseases.