The face is the most sensitive region of the body, and many individuals suffer with facial tissue defects. These patients have their social and psychological life impaired due to functional and aesthetic problems. Rehabilitating these patients with craniofacial deformities, whether congenital or acquired, has been a challenge for multidisciplinary teams. Facial defects can result from trauma, surgical resections, congenital anomalies, acquired infections like leishmaniasis and burns. The most commonly used materials for extraoral prosthesis include acrylic, vinyl, and polyurethane resins and silicone elastomers. This clinical report describes an oncological nasal defect which was rehabilitated with custom-made sculpted polymethyl methacrylate (PMMA) resin prosthesis which was retained by spectacles.