Urolithiasis is a common disease in urology, which produce great adverse influence on people's lives and health. Management of renal stones can be classified into prevention and management that are focus on life-style modification. Aim of the study: The study aimed to assess needs of patients with renal stones undergoing percutaneous nephrolithotomy. Design: A descriptive exploratory research design was used in this study. Setting: The study was conducted in urology department at El Fayoum General Hospital. Subjects: A purposive sample of (80) adult patients from both sex were included in the study. Tools: Two tools were used for data collection. Tool I: Patients' structured interview questionnaire: which included (a) Patients' demographic data (b) Patients' health history Tool II: Needs assessment questionnaire: This tool was used to assess patient's needs (Physical, Psychological, Social, spiritual and learning needs). Result: The present study illustrates that, 53.8% of the studied patients had low level of needs, while 46.2% had high level of needs, regarding patients' medical history 72.5% of them were have renal colic. Also, 72.5 % of them took analgesics to relieve these symptoms. Conclusion: There were a highly statistically significant correlation between spiritual needs and physical needs of the studied patients Recommendation: Design educational program for patients with renal stones to increase awareness regarding the disease to prevent recurrence of renal stone.